中文名 | 帕拉米韋 |
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英文名 | peramivir |
中文別名 | 帕拉米韋三水合物 |
英文別名 | 更多 |
描述 | Peramivir (RWJ 270201; Rapiacta; BCX 1812)是高活性的流感病毒神經(jīng)氨酸苷酶抑制劑,IC50的中位值為0.09 nM。 |
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相關(guān)類別 | 信號通路 >> 抗感染 >> 流感病毒 研究領(lǐng)域 >> 感染 |
參考文獻 | [1]. Louie JK, Yang S, Yen C, Acosta M, Schechter R, Uyeki TM.Use of Intravenous Peramivir for Treatment of Severe Influenza A(H1N1)pdm09.PLoS One. 2012;7(6):e40261. [2]. Sakata H.Clinical efficiency in children treated with intravenous drip infusion of peramivirJpn J Antibiot. 2011 Dec;64(6):383-7. [3]. Abed Y, Pizzorno A, Boivin G.Therapeutic Activity of Intramuscular Peramivir in Mice Infected with a Recombinant Influenza A/WSN/33 (H1N1) Virus Containing the H275Y Neuraminidase Mutation.Antimicrob Agents Chemother. 2012 Aug;56(8):4375-80. [4]. Shobugawa Y, Saito R, Sato I, Kawashima T, Dapat C, Dapat IC, Kondo H, Suzuki Y, Saito K, Suzuki H.Clinical effectiveness of neuraminidase inhibitors-oseltamivir, zanamivir, laninamivir, and peramivir-for treatment of influenza A(H3N2) and A(H1N1)pdm09 infection: an observational study in the 2010-2011 influenza season in Japan.J Infect Chemother. 2012 May 29. [5]. Yu Y, Garg S, Yu PA, Kim HJ, Patel A, Merlin T, Redd S, Uyeki TM.Peramivir use for treatment of hospitalized patients with influenza A(H1N1)pdm09 under emergency use authorization, October 2009-June 2010.Clin Infect Dis. 2012 Jul;55(1):8-15. |
分子式 | C15H34N4O7 |
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分子量 | 382.453 |
精確質(zhì)量 | 382.242737 |
PSA | 179.71000 |
LogP | 1.69890 |
Rapiacta trihydrate |
Peramivir Trihydrate |
QW7Y7ZR15U |
peramivir hydrate |
BCX 1812 trihydrate |
CS-0732 |
UNII-QW7Y7ZR15U |
(1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid,trihydrate |
(1S,2S,3S,4R)-3-[(1S)-1-Acetamido-2-ethylbutyl]-4-[(diaminomethylene)amino]-2-hydroxycyclopentanecarboxylic acid trihydrate |
Cyclopentanecarboxylic acid, 3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(diaminomethylene)amino]-2-hydroxy-, (1S,2S,3S,4R)-, hydrate (1:3) |