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當(dāng)前位置:杭州昊鑫生物科技股份有限公司>>MCE>>抑制劑>> HY-100558Bafilomycin A1抑制劑
HY-100558
MCE
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杭州市
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更新時(shí)間:2023-05-22 12:34:12瀏覽次數(shù):434次
聯(lián)系我時(shí),請(qǐng)告知來自 制藥網(wǎng)CAS號(hào) | 88899-55-2 | 產(chǎn)地 | 進(jìn)口 |
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級(jí)別 | 其他 |
注:本產(chǎn)品僅用于科研,不可用于臨床
生物活性 | Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis[1][2][3]. | ||||||||||||||||
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IC50 & Target |
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體外研究 (In Vitro) | Bafilomycin A1 is treated to different types of membrane ATPases with the I50 of 400 nmol/mg, 4 nmol/mg and 50 nmol/mg for the vacuolar ATPases of a fungus (N. crassa), a plant (Z. mays), and an animal (bovine abrenal medulla). The I50 values refer as μmol of Bafilomycin A1 per mg of protein giving 50% inhibition of ATPase activity[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
體內(nèi)研究 (In Vivo) | Chronic treatment with low-dose Bafilomycin A1 (0.1 mg/kg) slightly inhibits the tumor volume, but the final tumor volume does not differ significantly from the control. However, chronic treatment with high dose Bafilomycin A1 (1 mg/kg) inhibits the tumor growth significantly, compared with controls, after 21 days[8]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
分子量 | 622.83 | ||||||||||||||||
性狀 | Solid | ||||||||||||||||
Formula | C35H58O9 | ||||||||||||||||
CAS 號(hào) | 88899-55-2 | ||||||||||||||||
中文名稱 | 巴佛洛霉素A1;巴弗洛霉素A1 | ||||||||||||||||
結(jié)構(gòu)分類 |
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來源 | Streptomyces griseus strains | ||||||||||||||||
運(yùn)輸條件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
儲(chǔ)存方式 | -80°C, protect from light | ||||||||||||||||
溶解性數(shù)據(jù) | In Vitro: DMSO : 100 mg/mL (160.56 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) 配制儲(chǔ)備液
* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液;一旦配成溶液,請(qǐng)分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。 In Vivo: 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都?qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液,再依次添加助溶劑: ——為保證實(shí)驗(yàn)結(jié)果的可靠性,澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件,適當(dāng)保存;體內(nèi)實(shí)驗(yàn)的工作液,建議您現(xiàn)用現(xiàn)配,當(dāng)天使用; 以下溶劑前顯示的百
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